Clinical Insight for Practitioners Treating Complex Chronic Illness
Dr. Melanie Stein, ND shares the cellular-level frameworks, emerging research, and clinical reasoning behind her work with treatment-resistant Lyme, POTS, MCAS, mold illness, and long COVID. Built for colleagues managing these same complex cases.
Dr. Melanie Stein, ND
Dr. Melanie Stein, ND is Medical Director of Restorative Health Clinic in Portland, Oregon, where her practice focuses on complex, multisystem chronic illness: Lyme and tick-borne disease, POTS, MCAS, mold illness, and long COVID.
Her clinical approach centers on cell membrane and cellular signaling dysfunction as a shared driver across these presentations, rather than treating each diagnosis in isolation.
She is the author of Breaking Through Chronic Illness: The Science of Cellular Repair and the Path to Lasting Recovery, and speaks regularly on cellular mechanisms in chronic illness for both patient and professional audiences.
For practitioners managing patients who have not responded to standard protocols, her work offers a different starting point: not another diagnosis to add to the list, but a mechanism to investigate.
What Dr. Stein Shares With Practitioners
Practical Insights for Your Practice
Mechanism-Based Frameworks
How cell membrane dysfunction, mitochondrial impairment, and dysregulated signaling present across seemingly unrelated diagnoses, and where that changes your differential.
Case-Level Reasoning
How Dr. Stein approaches patients whose labs look normal but whose symptoms do not resolve, including where standard workups miss what is driving the presentation.
Emerging Research
Relevant findings in cellular health, chronic inflammatory response, and treatment-resistant complex illness, summarized for clinical use rather than patient consumption.
Speaking and Education Updates
Notice of conferences, trainings, and talks where these frameworks are covered in more depth.
Practitioner Consultation Services
Collaborative case review sessions where Dr. Stein meets with practitioners to discuss complex patients, evaluate clinical patterns, review available labs and history, and identify considerations that may help guide further evaluation and care planning.
Stay Connected With Dr. Stein
Get practitioner-focused clinical insights, research, and case reasoning on complex chronic illness, along with updates on speaking and professional education, directly from Dr. Stein.
We welcome connections with fellow practitioners. Tell us a little about you and your practice, and our team will follow up with you personally.
