Mast Cell Activation Syndrome (MCAS) Treatment in Portland, OR

Understanding MCAS: A Complex, Systemic Condition

Mast Cell Activation Syndrome (MCAS) is a chronic, multisystem disorder caused by overactive mast cells releasing excessive inflammatory mediators such as histamine. These reactions can result in a wide range of debilitating symptoms that affect the skin, gut, respiratory system, cardiovascular system, and nervous system. At Restorative Health Clinic in Portland, Oregon, we offer personalized, root-cause-focused care to help patients with MCAS find lasting relief and improved quality of life.

Mast cells are a vital part of the immune system, defending the body from pathogens and environmental toxins. In MCAS, these cells become hypersensitive and release large amounts of mediators—even without clear threats—triggering widespread inflammation and dysfunction.

Diagnosing MCAS can be difficult, as symptoms mimic other conditions. However, with expert evaluation and a comprehensive approach, effective treatments are possible.

Common Symptoms of MCAS

Skin Reactions

• Flushing, itching, hives, swelling

• Dermatographia (raised skin lines when scratched)

Gastrointestinal Symptoms

• Bloating, abdominal pain, nausea, diarrhea

Respiratory Symptoms

• Wheezing, nasal congestion, shortness of breath

Cardiovascular Symptoms

• Low blood pressure, dizziness, fainting

• Rapid or irregular heart rate (POTS is often co-diagnosed)

Neurological Symptoms

• Brain fog, fatigue, poor memory

• Headaches, light and sound sensitivity

We can help provide answers as to why you aren’t getting better.

Root Causes and Common Triggers of MCAS

Environmental Triggers

• Pollen, mold, dust, fragrances, cleaning products

Food Sensitivities

• High-histamine foods: aged cheese, wine, fermented foods

• Preservatives and artificial additives

Medications

• NSAIDs, antibiotics, opioids

Hormonal and Emotional Stress

• Menstrual cycles, pregnancy, menopause

• Physical or emotional stress

Chronic Infections & Coexisting Conditions

• Lyme disease, Epstein-Barr Virus (EBV), mold illness

• POTS, Ehlers-Danlos Syndrome (EDS), autoimmune conditions

Genetic Predisposition

• Family history of allergies or mast cell-related disorders

How We Diagnose and Treat MCAS at Restorative Health Clinic

How We Diagnose MCAS at Restorative Health Clinic

Our diagnostic process includes:

• Mast Cell Mediator Testing: Histamine, tryptase, prostaglandins

• Advanced Labs: Assess inflammation, immune status, and toxin exposure

• Detailed Medical History: Identify patterns, triggers, and co-conditions such as POTS or chronic infections

Comprehensive MCAS Treatment in Portland, OR

1. Symptom Stabilization

• Antihistamines (H1 and H2 blockers)
• Mast cell stabilizers: cromolyn sodium, quercetin
• Anti-inflammatory therapies

2. Trigger Identification and Lifestyle Adjustments

• Low-histamine diet plans
• Environmental detox strategies

3. Addressing Underlying Conditions

• Infection management (Lyme, mold, EBV)
• Gut healing protocols
• POTS management and autonomic support

4. Immune System and Nutritional Support

• Peptide therapy for immune modulation
• Micronutrient repletion (vitamins, minerals, antioxidants)

5. Hormonal and Stress Regulation

• Adaptogens, mindfulness, hormone balancing

6. IV Cell Membrane Stabilizing Detox Therapy

• Key ingredients: phosphatidylcholine, glutathione, and nutrients

          Benefits Include:

               Immune regulation

               Detoxification support

               Inflammation and reactivity

               Improved energy and cellular health

Begin Your Path to Healing

Living with MCAS can be overwhelming—but effective treatment is possible. At Restorative Health Clinic, we’re here to help you uncover triggers, calm your immune system, and rebuild your resilience.