Thyroid dysfunction in Fibromyalgia 2 Central Regulatory Dysfunction – unreliable TSH

2. Hypothalamic Regulatory Dysfunction or control center dysfunction is a very prevalent factor in thyroid dysfunction seen in fibromyalgia syndrome.

Control center inadequacy in regulating normal release of TSH and basal lowered fT3 levels are a strong cumbersome problem in fibromyalgia. Typically all lab parameters are low normal, with normal levels of TSH and lower levels of fT4 and fT3.

Fibromyalgia patients respond really well to microdoses of T3 therapy clinically. We accompany T3 therapy with cortisol levels to ensure a satisfactory response.

Action item: Get your TSH, fT4, fT3 levels tested to ensure adequate T3 levels to stimulate metabolism and energy production.

Thyroid function in patients with fibromyalgia syndrome.

Patients with fibromyalgia has significantly lower secretion of thyrotropin and thyroid hormones in response to TRH test.

Serum thyroid stimulating hormone in assessment of severity of tissue hypothyroidism.

TSH is a poor measure for estimating the clinical and metabolic severity of primary overt thyroid failure. This is in sharp contrast to the high diagnostic accuracy of TSH measurement for early diagnosis of hypothyroidism.

There is no correlation between the different parameters of target tissues and serum TSH.

Neuroendocrine and hormonal perturbations and relations to the serotonergic system in fibromyalgia patients.

The degree to which TSH can be stimulated is decreased in fibromyalgia patients.

Lowered basal values of  free triiodothyronine (fT3) was found in fibromyalgia patients.